Happy 🎂birthday Twitter Saipallavi @sweetha_reddy 💐. My puppy Chummmmah 😘

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Pallavi started shooting in February 2018 for the film Padi Padi Leche Manasu with Sharwanand, which under performed at the box office. In December, several news outlets reported that she refused to accept her full remuneration, expressing solidarity with the producers for the failure of the film. In 2019, she portrayed an autistic girl in the psychological thriller Athiran opposite Fahadh Faasil.

In 2020, she was recognised by Forbes magazine as one of India's 30 under 30. She was the only person from film industry in that list.

She also acted in a Netflix anthology film series Paava Kadhaigal segment Oor Iravu directed by Vetrimaaran.[citation needed] In 2021, she starred in the romantic drama Love Story alongside Naga Chaitanya in her second collaboration with Sekhar Kammula after Fidaa (2017) and Shyam Singa Roy opposite Nani in their second collaboration after MCA. Her upcoming film is Virata Parvam opposite Rana Daggubati.

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The year 2017 marked her debut in Telugu with Sekhar Kammula's Fidaa, in the role of Bhanumathi, a feisty village girl from Telangana.

Her performance in the film is regarded as one of the "100 Greatest Performances of the Decade" by Film Companion. Her next project with director A. L. Vijay was Diya, which is a Tamil–Telugu bilingual film.

Later, she starred in the Tamil movie Maari 2, a sequel to Maari, opposite Dhanush, directed by Balaji Mohan. A song from the movie, Rowdy Baby, is the most viewed song in YouTube from South India.